Clodronate Disodium EP Impurity A Pyridinium Salt CAS 134757-52-1 (free acid)

Purity ≥95%In StockPharmacopoeial Impurity Standards
CAS No.134757-52-1 (free acid)
Molecular FormulaC4H10Cl2O6P2
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Clodronate Disodium EP Impurity A Pyridinium Salt CAS 134757-52-1 (free acid) chemical structure

Description

Structurally, Clodronate Disodium EP Impurity A Pyridinium Salt (C4H10Cl2O6P2C5H5N) contains an amide group, a phosphate ester group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 366.07 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

CATO supplies Clodronate Disodium EP Impurity A Pyridinium Salt (CAS 134757-52-1 (free acid)), a pharmacopoeial impurity reference standard (molecular formula C4H10Cl2O6P2C5H5N, MW 366.07 g/mol) used for the identification and quantification of trace impurities in APIs.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

As a certified reference material (CRM), Clodronate Disodium EP Impurity A Pyridinium Salt meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC4H10Cl2O6P2 C5H5N
Molecular Weight366.07 g/mol
Purity≥95%
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityLight-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)2.0
Halogen ContentCl-containing
Nitrogen Atoms1

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